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Preheat oven to 350°F.
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Prepare pasta according to package directions. Drain. Set aside.
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Place 2 tablespoons butter in a large, heavy-bottom pot. Set over medium heat and melt butter.
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Add flour. Whisk until thoroughly combined to form a roux.
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Slowly whisk in milk.
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Slowly whisk in half-and-half.
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Add mustard, BBQ sauce, salt and pepper, to taste, and whisk well to combine fully.
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Bring sauce to a simmer. Allow to simmer, whisking constantly, 8 to 10 minutes to develop the flavors.
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A little at a time, add white Cheddar and Parmesan cheeses. Whisk well after every addition and allow to melt before adding next batch.
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Stir in the corn, jalapeños and parsley. Remove from heat.
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Stir in the macaroni.
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Add the cubed sharp Cheddar and Colby cheeses. Stir to combine.
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Spoon the macaroni and cheese mixture into a buttered 13-by-9-inch baking dish.
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Place remaining one-quarter cup of butter in a small sauce pan. Melt over medium heat.
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In a medium bowl, combine cracker, panko and unseasoned bread crumbs.
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Add melted butter and stir to combine.
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Sprinkle the crumb mixture over the macaroni and cheese.
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Place in preheated oven. Bake until bubbly and browned on top, about 40 minutes.
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Serve hot.